The veteran, who was stunned by the Australian in Tokyo three years ago, touched in 4mins 02.19secs at a packed La Defense Arena ahead of an evening final on day one of the nine-day meet. Racing in the same heat, Titmus went out hard and led through 300m before Ledecky came storming home to win by a fingertip. Titmus hit the wall in 4:02.46, well outside her 3:55.38 world record as both swimmers conserved energy.

New Zealand rising star and current world champion Erika Fairweather was third quickest in 4:02.55, a fraction clear of Canadian Summer McIntosh, who snatched the world record last year before Titmus took it back.

"Good to walk out to a full stadium for our prelims race," said Ledecky, who will also swim the 800m and 1500m in Paris but has dropped the 200m. "It felt very similar to our Olympic trials a few weeks back, so I'm excited to see the finals atmosphere tonight as well and just happy to get a good first one under the belt."

Titmus said the race helped "blow the cobwebs out" and denied coming second gave Ledecky any psychological advantage.

"I don't think so. It's a heats swim," said the Australian, who broke the 200m freestyle world record and swam the second quickest 400m ever at the Australian trials last month. "The only job for me was to get in the middle lanes (for the final) and I tried to conserve as much as I could."

Lukas Maertens topped the times in the men's 400m freestyle heats in 3:44,13 ahead of Brazil's Guilherme Costa. The German is red-hot favourite for Saturday's final, arriving in Paris more than a second quicker than anyone else this season after clocking the best time since 2012 in April. Australian pair Elijah Winnington and Sam Short, both former world champions, were fourth and fifth respectively with current world champion Kim Woo-min of South Korea seventh.

Nothing to prove

Britain's Adam Peaty clocked a comfortable 59.18 heat swim to launch the defence of his 100m breaststroke crown as he bids to become only the second man to win three straight gold in the same individual event after Michael Phelps. His victory in Tokyo 2020, which followed his 2016 triumph in Rio, leaves him with the chance of equalling Phelps as the only male swimmers to have won the same event at three successive Olympics.

Dutchman Caspar Corbeau who clocked in at 59.04 led the way into the semi-finals.

"I was like I don't really have to push anything too far, I don't have to prove anything," said Peaty, who is back in top form after a break for mental health troubles. "We can't win the battle now, we have to win it tomorrow."

Peaty has lowered the world record five times and is arguably the greatest ever over the distance. His main rival is expected to be China's Qin Haiyang, who burst on the scene in Peaty's absence at last year's world championships by sweeping the 50-100-200m titles. But Qin, reportedly among the 23 Chinese swimmers embroiled in a doping scandal that rocked the sport this year, was only ninth quickest in 59.58.

In the day's other heats, American world record holder Gretchen Walsh was fourth fastest into the women's 100m butterfly semi-finals in 56.75. The 21-year-old is at her first Olympics after shattering Sarah Sjoestroem's eight-year-old world best at the US trials to position her as the woman to beat. But it was Tokyo silver medallist Zhang Yufei, also allegedly among the swimmers caught up in the same doping scandal as Qin, who touched first in 56.50. Japan's Mizuki Hirai was second fastest ahead of American Torri Huske. Australia's Emma McKeon, the queen of the pool in Tokyo with seven medals, came fifth and Canadian defending champion Maggie McNeil seventh.

Meanwhile, Australia's world-leading women's 4x100m freestyle relay team stormed through their heat in 3:31.57, nearly two seconds clear of the United States. Undefeated at the Olympics since 2012, they have owned the world record since 2014. China was fastest into the men's 4x100m freestyle relay final ahead of Australia and Britain.